THE MEDICINE GAME, a film six years in the making, shares the remarkable journey of two brothers from the Onondoga Nation driven by a single goal-to beat the odds and play the sport of lacrosse for national powerhouse Syracuse University. The Onondaga Nation, tucked away in central New York State, is a sovereign Native American community known to produce some of the top lacrosse players in the world. The Iroquois people play a ceremonial game of lacrosse, referred to as the "medicine game" - a very important medicine ceremony played to ward off sicknesses from the tribe. The obstacles in the brothers' way are frequent and daunting, but their love for the game, each other, and their family's unyielding determination propels these young men towards their dream.